Drug hypersensitivity reactions are a serious problem in the management of the HIV-positive patient, and antiretroviral drugs are currently the main cause of these reactions. We report a case of cutaneous hypersensitivity associated with a new protease inhibitor Darunavir. Patient had a maculopapular rash and fever after the second dose of the antiretroviral. After withdrawal of the drug and use of hydrocortisone, the patient had a good outcome, being released in good general condition after 3 days of hospitalization.
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